In dogs, it’s the upper fourth premolar — the carnassial — which I saw in three slab-fracture cases last week from antlers and marrow bones. Those typically require extraction or a root canal, so prevention matters: if a chew is harder than your fingernail, skip it.
Had a lab crack that same tooth on a smoked femur; since then I go by your “harder than your fingernail” rule and stick to VOHC-approved chews (https://www.vohc.org/)… If you’ve got a power chewer, a chilled stuffed Kong keeps them busy without the fracture risk; just retire it if they start shaving chunks off, because even rubber can turn into a swallow hazard. If it could double as a doorstop, it’s not a chew.